Anti-Inflammatory Supplements

Build your personalized anti-inflammatory supplement protocol

Fish Oil (EPA/DHA)

Essential fatty acids with powerful anti-inflammatory effects

Evidence: 9.2/10 Anti-Inflammatory: 9.0/10
Omega-3 2-4g EPA/DHA daily

Curcumin

Active compound from turmeric with potent anti-inflammatory properties

Evidence: 9.0/10 Anti-Inflammatory: 9.0/10
Polyphenols 500-1000mg with piperine

Sulforaphane

Potent Nrf2 activator from broccoli

Evidence: 8.9/10 Anti-Inflammatory: 9.0/10
Antioxidants 40-60mg

Boswellia Serrata

Herbal extract that inhibits 5-LOX inflammatory pathway

Evidence: 8.0/10 Anti-Inflammatory: 8.0/10
Herbs 300-500mg AKBA daily

Quercetin

Flavonoid with anti-inflammatory and antihistamine properties

Evidence: 8.0/10 Anti-Inflammatory: 8.0/10
Polyphenols 500-1000mg daily

N-Acetylcysteine (NAC)

Precursor to glutathione with anti-inflammatory effects

Evidence: 8.0/10 Anti-Inflammatory: 8.0/10
Amino Acids 600-1200mg daily
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Astaxanthin

Powerful carotenoid antioxidant with anti-inflammatory effects

Evidence: 7.3/10 Anti-Inflammatory: 8.0/10
Antioxidants 4-12mg daily

Tart Cherry Extract

Anthocyanin-rich extract

Evidence: 8.2/10 Anti-Inflammatory: 8.0/10
Polyphenols 480mg extract

PEA (Palmitoylethanolamide)

Endogenous fatty acid amide

Evidence: 8.5/10 Anti-Inflammatory: 8.0/10
Other 600-1200mg

Melatonin

Sleep hormone with anti-inflammatory properties

Evidence: 8.3/10 Anti-Inflammatory: 8.0/10
Other 3-10mg

Serrapeptase

Proteolytic enzyme

Evidence: 7.7/10 Anti-Inflammatory: 8.0/10
Enzymes 60,000-120,000 SPU

Krill Oil

Phospholipid-bound omega-3s

Evidence: 8.5/10 Anti-Inflammatory: 8.0/10
Omega-3 1-2g daily

Andrographis

King of Bitters herb

Evidence: 7.8/10 Anti-Inflammatory: 8.0/10
Herbs 400-600mg

Berberine

Alkaloid with metabolic benefits

Evidence: 8.5/10 Anti-Inflammatory: 8.0/10
Herbs 500mg 3x daily

Butyrate

Short-chain fatty acid

Evidence: 8.0/10 Anti-Inflammatory: 8.0/10
Other 300-900mg

Baicalin (Skullcap)

Chinese skullcap flavonoid

Evidence: 7.9/10 Anti-Inflammatory: 8.0/10
Herbs 250-500mg

Fisetin

Senolytic flavonoid

Evidence: 7.8/10 Anti-Inflammatory: 8.0/10
Polyphenols 100-500mg

Hydroxytyrosol

Olive oil phenol

Evidence: 7.9/10 Anti-Inflammatory: 8.0/10
Polyphenols 20-50mg

Proteolytic Enzyme Blend

Systemic enzymes

Evidence: 7.6/10 Anti-Inflammatory: 8.0/10
Enzymes Per label

Vitamin D3

Essential vitamin that modulates immune response and inflammation

Evidence: 8.7/10 Anti-Inflammatory: 7.0/10
Vitamins 2000-4000 IU daily

Magnesium

Essential mineral that helps regulate inflammatory response

Evidence: 7.9/10 Anti-Inflammatory: 7.0/10
Minerals 200-400mg daily

Ginger Extract

Traditional anti-inflammatory herb that inhibits COX and LOX

Evidence: 8.0/10 Anti-Inflammatory: 7.0/10
Herbs 1-2g extract daily

Resveratrol

Polyphenol that activates SIRT1 and reduces inflammation

Evidence: 7.3/10 Anti-Inflammatory: 7.0/10
Polyphenols 150-500mg daily

Bromelain

Proteolytic enzyme from pineapple with anti-inflammatory effects

Evidence: 7.0/10 Anti-Inflammatory: 7.0/10
Enzymes 500-1000mg daily

CoQ10 (Ubiquinol)

Mitochondrial antioxidant

Evidence: 8.0/10 Anti-Inflammatory: 7.0/10
Antioxidants 100-300mg

Lion’s Mane Mushroom

Neuroprotective mushroom

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Mushrooms 1000-3000mg

Turkey Tail Mushroom

Immune-modulating mushroom

Evidence: 7.8/10 Anti-Inflammatory: 7.0/10
Mushrooms 1-3g extract

Vitamin K2 (MK-7)

Fat-soluble vitamin

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Vitamins 100-200mcg

Pomegranate Extract

Ellagitannin-rich extract

Evidence: 7.9/10 Anti-Inflammatory: 7.0/10
Polyphenols 500-1000mg

Grape Seed Extract

OPC-rich extract

Evidence: 7.7/10 Anti-Inflammatory: 7.0/10
Polyphenols 100-300mg

Pine Bark Extract

Maritime pine bark

Evidence: 7.9/10 Anti-Inflammatory: 7.0/10
Polyphenols 100-200mg

Holy Basil (Tulsi)

Ayurvedic adaptogen

Evidence: 7.4/10 Anti-Inflammatory: 7.0/10
Herbs 300-600mg

Rhodiola Rosea

Arctic root adaptogen

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Herbs 200-400mg

Milk Thistle

Liver-protective herb

Evidence: 7.8/10 Anti-Inflammatory: 7.0/10
Herbs 200-400mg

Ashwagandha

Ayurvedic adaptogen

Evidence: 8.0/10 Anti-Inflammatory: 7.0/10
Herbs 600-1000mg

Reishi Mushroom

Mushroom of immortality

Evidence: 7.7/10 Anti-Inflammatory: 7.0/10
Mushrooms 1000-2000mg

Cordyceps

Energy-enhancing mushroom

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Mushrooms 1000-3000mg

Chaga Mushroom

Antioxidant-rich mushroom

Evidence: 7.4/10 Anti-Inflammatory: 7.0/10
Mushrooms 500-1500mg

Maitake Mushroom

Immune-enhancing mushroom

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Mushrooms 1000-2000mg

Spermidine

Autophagy inducer

Evidence: 7.9/10 Anti-Inflammatory: 7.0/10
Other 1-5mg

Urolithin A

Pomegranate metabolite

Evidence: 8.0/10 Anti-Inflammatory: 7.0/10
Other 250-500mg

Akkermansia

Next-gen probiotic

Evidence: 8.1/10 Anti-Inflammatory: 7.0/10
Probiotics 10 billion CFU

White Willow Bark

Natural aspirin precursor

Evidence: 7.3/10 Anti-Inflammatory: 7.0/10
Herbs 240-480mg salicin

Cat’s Claw

Amazonian vine

Evidence: 7.4/10 Anti-Inflammatory: 7.0/10
Herbs 350-500mg

Devil’s Claw

African anti-inflammatory

Evidence: 7.2/10 Anti-Inflammatory: 7.0/10
Herbs 600-2400mg

Feverfew

Migraine prevention herb

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Herbs 100-300mg

Gotu Kola

Ayurvedic cognitive herb

Evidence: 7.2/10 Anti-Inflammatory: 7.0/10
Herbs 600-1200mg

Schisandra Berry

Five-flavor berry

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Herbs 500-1500mg

Aged Garlic Extract

Odorless garlic

Evidence: 7.7/10 Anti-Inflammatory: 7.0/10
Herbs 600-1200mg

Apigenin

Chamomile flavonoid

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Polyphenols 50-100mg

Luteolin

Neuroinflammation fighter

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Polyphenols 100-200mg

Hesperidin

Citrus flavonoid

Evidence: 7.5/10 Anti-Inflammatory: 7.0/10
Polyphenols 500-1000mg

Pterostilbene

Methylated resveratrol

Evidence: 7.7/10 Anti-Inflammatory: 7.0/10
Polyphenols 50-150mg

Ellagic Acid

Berry polyphenol

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Polyphenols 200-400mg

Mangosteen Extract

Xanthone-rich fruit

Evidence: 7.3/10 Anti-Inflammatory: 7.0/10
Polyphenols 500-1000mg

NMN

NAD+ precursor

Evidence: 8.0/10 Anti-Inflammatory: 7.0/10
Other 250-500mg

Ergothioneine

Unique mitochondrial antioxidant

Evidence: 7.8/10 Anti-Inflammatory: 7.0/10
Antioxidants 5-25mg

Pau d’Arco

South American bark

Evidence: 6.9/10 Anti-Inflammatory: 7.0/10
Herbs 1-2g bark

Sea Buckthorn Oil

Omega-7 rich oil

Evidence: 7.4/10 Anti-Inflammatory: 7.0/10
Other 2-4g oil

L. reuteri

Probiotic strain

Evidence: 7.7/10 Anti-Inflammatory: 7.0/10
Probiotics 1-5 billion CFU

S. boulardii

Beneficial yeast

Evidence: 7.8/10 Anti-Inflammatory: 7.0/10
Probiotics 5-10 billion CFU

B. longum

Core gut probiotic

Evidence: 7.6/10 Anti-Inflammatory: 7.0/10
Probiotics 10-50 billion CFU

Sea Cucumber

Marine chondroitin

Evidence: 7.2/10 Anti-Inflammatory: 7.0/10
Other 1000-3000mg

Lithium Orotate

Trace mineral for brain

Evidence: 7.3/10 Anti-Inflammatory: 7.0/10
Minerals 5-10mg

Olive Leaf Extract

Mediterranean herb

Evidence: 7.2/10 Anti-Inflammatory: 7.0/10
Herbs 500-1000mg

Vitamin C

Antioxidant vitamin that modulates inflammatory response

Evidence: 7.5/10 Anti-Inflammatory: 6.0/10
Vitamins 500-1000mg daily

Green Tea Extract (EGCG)

Catechins with anti-inflammatory and antioxidant properties

Evidence: 7.7/10 Anti-Inflammatory: 6.0/10
Polyphenols 300-500mg EGCG daily

Zinc

Essential mineral that regulates immune and inflammatory response

Evidence: 7.6/10 Anti-Inflammatory: 6.0/10
Minerals 15-30mg daily

Black Seed Oil

Traditional remedy with thymoquinone as active compound

Evidence: 6.5/10 Anti-Inflammatory: 6.0/10
Herbs 1-2 tsp daily

Probiotics

Beneficial bacteria that modulate inflammation through gut health

Evidence: 7.9/10 Anti-Inflammatory: 6.0/10
Other 10-50 billion CFU daily

Vitamin E

Fat-soluble antioxidant vitamin

Evidence: 7.5/10 Anti-Inflammatory: 6.0/10
Vitamins 200-400 IU mixed

Glucosamine

Joint support supplement with anti-inflammatory effects

Evidence: 7.5/10 Anti-Inflammatory: 6.0/10
Other 1500mg daily

Alpha Lipoic Acid

Universal antioxidant

Evidence: 7.4/10 Anti-Inflammatory: 6.0/10
Antioxidants 300-600mg

Shiitake Mushroom

Culinary medicinal mushroom

Evidence: 7.3/10 Anti-Inflammatory: 6.0/10
Mushrooms 1000-3000mg

Glycine

Simple amino acid

Evidence: 7.5/10 Anti-Inflammatory: 6.0/10
Amino Acids 3-5g

Taurine

Sulfur amino acid

Evidence: 7.4/10 Anti-Inflammatory: 6.0/10
Amino Acids 1-3g

L-Glutamine

Gut health amino acid

Evidence: 7.6/10 Anti-Inflammatory: 6.0/10
Amino Acids 5-10g

L-Arginine

NO precursor

Evidence: 7.3/10 Anti-Inflammatory: 6.0/10
Amino Acids 3-6g

L-Carnitine

Mitochondrial nutrient

Evidence: 7.5/10 Anti-Inflammatory: 6.0/10
Amino Acids 2-3g

L-Citrulline

Superior NO precursor

Evidence: 7.4/10 Anti-Inflammatory: 6.0/10
Amino Acids 6-8g

Collagen Peptides

Structural protein

Evidence: 7.6/10 Anti-Inflammatory: 6.0/10
Other 10-20g

Creatine Monohydrate

ATP regeneration

Evidence: 8.5/10 Anti-Inflammatory: 6.0/10
Amino Acids 3-5g

Boron

Trace mineral

Evidence: 7.0/10 Anti-Inflammatory: 6.0/10
Minerals 3-10mg

Chromium

Blood sugar mineral

Evidence: 7.3/10 Anti-Inflammatory: 6.0/10
Minerals 200-400mcg

Bilberry Extract

Eye health berry

Evidence: 7.2/10 Anti-Inflammatory: 6.0/10
Polyphenols 160-480mg

Elderberry

Immune-supporting berry

Evidence: 7.0/10 Anti-Inflammatory: 6.0/10
Polyphenols 500-1000mg

Hawthorn

Heart health herb

Evidence: 7.3/10 Anti-Inflammatory: 6.0/10
Herbs 300-900mg

Betaine (TMG)

Methyl donor

Evidence: 7.2/10 Anti-Inflammatory: 6.0/10
Other 1-3g

Chlorophyll

Plant pigment

Evidence: 7.0/10 Anti-Inflammatory: 6.0/10
Antioxidants 100-300mg

Humic/Fulvic Acid

Mineral absorption enhancer

Evidence: 6.8/10 Anti-Inflammatory: 6.0/10
Other 250-500mg

HMB

Leucine metabolite

Evidence: 7.2/10 Anti-Inflammatory: 6.0/10
Other 3g

Vitamin A

Fat-soluble vitamin

Evidence: 7.2/10 Anti-Inflammatory: 6.0/10
Vitamins 5000-10000 IU

B-Complex

Complete B vitamins

Evidence: 7.4/10 Anti-Inflammatory: 6.0/10
Vitamins 1 complex

Aloe Vera

Soothing plant extract

Evidence: 7.0/10 Anti-Inflammatory: 6.0/10
Herbs 200-400mg

Dandelion

Detox herb

Evidence: 6.8/10 Anti-Inflammatory: 6.0/10
Herbs 500-1500mg

Selenium

Trace mineral that supports antioxidant enzymes

Evidence: 6.8/10 Anti-Inflammatory: 5.0/10
Minerals 200mcg daily

Spirulina

Blue-green algae with anti-inflammatory and antioxidant properties

Evidence: 6.4/10 Anti-Inflammatory: 5.0/10
Other 3-8g daily

PQQ

Mitochondrial support

Evidence: 6.2/10 Anti-Inflammatory: 5.0/10
Other 10-20mg

Copper

Essential trace mineral

Evidence: 6.8/10 Anti-Inflammatory: 5.0/10
Minerals 1-2mg

Manganese

Trace mineral

Evidence: 6.5/10 Anti-Inflammatory: 5.0/10
Minerals 2-5mg

Beginner Anti-Inflammatory Stack

Essential supplements for those new to anti-inflammatory protocols

3 supplements

Joint Health Stack

Targeted support for joint pain and arthritis

4 supplements

Gut Health Stack

Support for digestive health and gut inflammation

4 supplements

Athletic Recovery Stack

Reduce exercise-induced inflammation

4 supplements

Comprehensive Protocol

Full spectrum anti-inflammatory support

6 supplements

Antioxidant Power Stack

Focused on reducing oxidative stress and inflammation

6 supplements

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